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Computer game viruses have spread in secret around the world. The virus, known as Bugster, infects a human host before taking over the body and mutating. These Bugsters seek to undermine the world and dominate the human race.

To defeat the Bugster, a gamer Kamen Rider is needed! Humans have developed the Kamen Rider system with the power of video games to combat the Bugster. With cooperation from the Ministry of Health and other national institutes that manage public health, the Genmu Corporation created the game machine called the Gamer Driver. By inserting the game software known as Rider Gashats into the Gamer Driver belt, the wearer becomes a Kamen Rider!

Four doctors have been chosen to become Kamen Riders meant to defeat the Bugster virus! A never seen before “Bugster vs. Game Rider!” and “Doctor vs. Doctor!” game battle is about to kick off!!

Emu Hojo / Kamen Rider Ex-Aid (Hiroki Iijima)
The protagonist of the story. A 24-year-old medical resident and gamer.

Hiiro Kagami / Kamen Rider Brave (Toshiki Seto)
The first hurdle that stands before our hero Emu. Though they may be the same age, Hiiro does not see Emu as an equal. Having graduated from an overseas university early, his colleagues refer to him as the “genius surgeon”.

Taiga Hanaya / Kamen Rider Snipe (Ukyo Matsumoto)
A silver-haired doctor!? An unconventional man just from his appearance alone. Taiga is in fact an unlicensed doctor of darkness. Why was he stripped of his medical license?

Asuna Karino / Poppi Pipopapo (Ruka Matsuda)
A nurse who assists Emu as Kamen Rider Ex-Aid. However, who on Earth is the colourful girl who looks like Asuna!?

Kuroto Dan (Tetsuya Iwanaga)
The developer of the belt-type game machine known as the Gamer Driver as well as the game software Rider Gashat. Both of these are used by the Kamen Riders to transform. He is also the young CEO of the game company Genmu Corporation.

Kiriya Kujo (Hayato Onozuka)
Dressed in sunglasses and an aloha shirt, as if he’s come back from a tropical resort, this eccentric man is a co-worker of Emu and Hiiro’s as well as a former co-work of Taiga’s. Though doctors are there to cure the living of their diseases, coroners are needed to turn up the hidden mysteries of the deceased’s cause of death! Unfortunately Emu is usually at the mercy of Kiriya’s trickster personality. Please look forward to this trickster’s success!

Pallad (Kai Shouma)
Dressed in black and adorned with psychedelic pixel patterns. Though he may have a smile on his face, Pallad is far from innocent. An executive of the Bugster, he aims to annihilate the human race. He will prove to be a formidable enemy of Emu’s in the future and will become a presence that holds the key to the story.